Publications
See PubMed and Google Scholar for complete lists of Mellis Lab papers.

Lab Members and Co-Mentees in Bold
* = equal contribution
# = corresponding


2026

Mellis IA*#, Wu M*, Daniel K*, Hong H, Guo Y*, Ho DD
bioRxiv 2026.03.31.715419 (2026). (In Review) http://dx.doi.org/10.64898/2026.03.31.715419

Mellis IA*#, Wu M*, Hong H*, Bowen A, Daniel K, Gherasim C, Pierce VM, Yin MT, Gordon A#, Guo Y#, Ho DD#
PLOS Pathogens 22 e1014218 (2026). http://dx.doi.org/10.1371/journal.ppat.1014218



2025

Zambrana JV*, Mellis IA*, Shotwell A, Maier HE, Saborio Y, Barillas C, Lopez R, Vasquez G, Plazaola M, Sanchez N, Ojeda S, Gilbertson I, Kuan G, Wang Q, Liu L, Balmaseda A, Ho DD#, Gordon A#
Nature Communications 16 (1) 10305 (2025). http://dx.doi.org/10.1038/s41467-025-65235-8

Mellis IA*, Wu M*, Hong H*, Tzang CC*, Bowen A*, Wang Q, Gherasim C, Pierce VM, Shah JG, Purpura LJ, Yin MT, Gordon A#, Guo Y#, Ho DD#
Cell Reports 44 (10) 116440 (2025). http://dx.doi.org/10.1016/j.celrep.2025.116440

Wang Q, Guo Y, Casner RG, Yu J, Nair MS, Ho J, Reddem ER, Mellis IA, Wu M, Tzang CC, Hong H, Huang Y, Shapiro L, Liu L, Ho DD
Nature Communications 16 (1) 6195 (2025). http://dx.doi.org/10.1038/s41467-025-61472-z

Mellis IA*, Wu M*, Wang Q*, Bowen A, Gherasim C, Valdez R, Shah JG, Purpura LJ, Yin MT, Gordon A, Guo Y#, Ho DD#
bioRxiv 2025.05.02.651777 (2025). http://dx.doi.org/10.1101/2025.05.02.651777

Wang Q*, Guo Y*, Mellis IA*, Wu M*, Mohri H, Gherasim C, Valdez R, Purpura LJ, Yin MT, Gordon A, Ho DD
Cell Reports 44 (4) 115543 (2025). http://dx.doi.org/10.1016/j.celrep.2025.115543

Wang Q*, Mellis IA*, Wu M*, Bowen A*, Gherasim C, Valdez R, Shah JG, Purpura LJ, Yin MT, Gordon A#, Guo Y#, Ho DD#
The Lancet Infectious Diseases 25 (3) e133-e134 (2025). http://dx.doi.org/10.1016/S1473-3099(25)00058-1



2024

Wang Q*, Mellis IA*, Guo Y*, Gherasim C, Valdez R, Gordon A#, Ho DD#, Liu L#
Cell Reports Medicine 5 (9) 101701 (2024). http://dx.doi.org/10.1016/j.xcrm.2024.101701

Wang Q*, Mellis IA*, Ho J*, Bowen A, Kowalski-Dobson T, Valdez R, Katsamba PS, Wu M, Lee C, Shapiro L, Gordon A#, Guo Y#, Ho DD#, Liu L#
Emerging Microbes & Infections 13 (1) 2402880 (2024). http://dx.doi.org/10.1080/22221751.2024.2402880

Wang Q*, Guo Y*, Schwanz LT*, Mellis IA*, Sun Y, Qu Y, Urtecho G, Valdez R, Stoneman E, Gordon A, Wang HH, Ho DD#, Liu L#
Emerging Microbes & Infections 13 (1) 2359004 (2024). http://dx.doi.org/10.1080/22221751.2024.2359004

Wang Q*, Guo Y*, Bowen A*, Mellis IA*, Valdez R, Gherasim C, Gordon A#, Liu L#, Ho DD#
Cell Host & Microbe 32 (3) 315–321.e3 (2024). http://dx.doi.org/10.1016/j.chom.2024.01.014

Jain N, Goyal Y, Dunagin MC, Cote CJ, Mellis IA, Emert B, Jiang CL, Dardani IP, Reffsin S, Arnett M, Yang W, Raj A
Cell Systems 15 (2) 315–321.e3 (2024). http://dx.doi.org/10.1016/j.cels.2024.01.001



2023

Wang Q*, Li Z*, Guo Y*, Mellis IA*, Iketani S, Liu M, Yu J, Valdez R, Lauring AS, Sheng Z, Gordon A, Liu L#, Ho DD#
iScience 26 (11) 108254 (2023). http://dx.doi.org/10.1016/j.isci.2023.108254

Goyal Y#, Busch GT, Pillai M, Li J, Boe RH, Grody EI, Chelvanambi M, Dardani IP, Emert B, Bodkin N, Braun J, Fingerman D, Kaur A, Jain N, Ravindran PT, Mellis IA, Kiani K, Alicea GM, Fane ME, Ahmed SS, Li H, Chen Y, Chai C, Kaster J, Witt RG, Lazcano R, Ingram DR, Johnson SB, Wani K, Dunagin MC, Lazar AJ, Weeraratna AT, Wargo JA, Herlyn M, Raj A#
Nature 620 (7974) 651-659 (2023). http://dx.doi.org/10.1038/s41586-023-06342-8

Wang Q, Bowen A, Tam AR, Valdez R, Stoneman E, Mellis IA, Gordon A, Liu L, Ho DD
The Lancet Infectious Diseases 23 (5) 527-528 (2023). http://dx.doi.org/10.1016/S1473-3099(23)00181-0



2022

Jiang CL, Goyal Y, Jain N, Wang Q, Truitt RE, Coté AJ, Emert B, Mellis IA, Kiani K, Yang W, Jain R, Raj A
Genome Biology 23 (1) 1-29 (2022). http://dx.doi.org/10.1186/s13059-022-02654-6



2021

Mellis IA, Edelstein HI, Truitt R, Goyal Y, Beck LE, Symmons O, Dunagin MC, Linares Saldana RA, Shah PP, Pérez-Bermejo JA, Padmanabhan A, Yang W, Jain R#, Raj A#
Cell Systems 12 (9) 885-899 (2021). http://dx.doi.org/10.1016/j.cels.2021.07.003

Boland MR, Liu J, Balocchi C, Meeker J, Bai R, Mellis I, Mowery DL, Herman D
AMIA Summits on Translational Science Proc. 2021 545-554 (2021).

Torre EA, Arai E, Bayatpour S, Jiang CL, Beck LE, Emert BL, Shaffer SM, Mellis IA, Fane ME, Alicea GM, Budinich KA, Weeraratna AT, Shi J, Raj A
Nature Genetics 53 (1) 76-85 (2021). http://dx.doi.org/10.1038/s41588-020-00749-z



2019

Kaur A, Ecker BL, Douglass SM, Kugel CH 3rd, Webster MR, Almeida FV, Somasundaram R, Hayden J, Ban E, Ahmadzadeh H, Franco-Barraza J, Shah N, Mellis IA, Keeney F, Kossenkov A, Tang HY, Yin X, Liu Q, Xu X, Fane M, Brafford P, Herlyn M, Speicher DW, Wargo JA, Tetzlaff MT, Haydu LE, Raj A, Shenoy V, Cukierman E, Weeraratna AT
Cancer Discovery 9 (1) 64-81 (2019). http://dx.doi.org/10.1158/2159-8290.CD-18-0193

Symmons O#, Chang M, Mellis IA, Kalish JM, Park J, Suszták K, Bartolomei MS, Raj A#
PLOS Genetics 15 (1) e1007874 (2019). http://dx.doi.org/10.1371/journal.pgen.1007874



2018

Rouhanifard SH, Mellis IA, Dunagin M, Bayatpour S, Jiang CL, Dardani I, Symmons O, Emert B, Torre E, Cote A, Sullivan A, Stamatoyannopoulos JA, Raj A
Nature Biotechnology 37 (1) 84-89 (2018). http://dx.doi.org/10.1038/nbt.4286



2017

Mellis IA, Gupte R, Raj A, Rouhanifard SH
Nature Methods 14 (8) 801-804 (2017). http://dx.doi.org/10.1038/nmeth.4332



2016

Berlyand Y, Weintraub D, Xie SX, Mellis IA, Doshi J, Rick J, McBride J, Davatzikos C, Shaw LM, Hurtig H, Trojanowski JQ, Chen-Plotkin AS
PLOS One 11 (1) e0147319 (2016). http://dx.doi.org/10.1371/journal.pone.0147319



2015


2013

Economides AN, Frendewey D, Yang P, Dominguez MG, Dore AT, Lobov IB, Persaud T, Rojas J, McClain J, Lengyel P, Droguett G, Chernomorsky R, Stevens S, Auerbach W, Dechiara TM, Pouyemirou W, Cruz JM Jr, Feeley K, Mellis IA, Yasenchack J, Hatsell SJ, Xie L, Latres E, Huang L, Zhang Y, Pefanis E, Skokos D, Deckelbaum RA, Croll SD, Davis S, Valenzuela DM, Gale NW, Murphy AJ, Yancopoulos GD
PNAS 110 (34) 1466-1472 (2013). http://dx.doi.org/10.1073/pnas.1217812110