Diverse forms of gene regulation underpin genotype-to-phenotype maps. We aim to discover mechanisms of gene regulation and harness them for genetic engineering and gene therapy applications, developing experimental and computational methods along the way. In Ian’s PhD thesis, he invented a single-molecule RNA FISH-based tool for visualizing and quantifying RNA editing with sub-single-cell resolution and he contributed to the development of other specialized RNA FISH-based methods for amplifying RNA FISH signal and for visualizing allelic expression in tissues. More recently, we published a study about transcriptional adaptation, a gene regulatory phenomenon that allows organisms to compensate for mutations. We are pursuing projects related to modeling gene regulatory networks and leveraging transcriptional adaptation for genetic engineering.