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• team 7
• Member 2
• Friend 1
• Co-Mentee 3
• Principal Investigator 1
• portals 1
• portal 1
• papers 28
• paper 28
• misc 4
• home 1
• projects 4
• project 4
• events 4
• positions 1
• position 1

team

• Maddie Wu
• Sofiia Shapovalova
• Ian Mellis
• Chien-Yu (Chihiro) Huang
• Hsiang Hong
• Yogesh Goyal
• Kristin Daniel

Member

• Sofiia Shapovalova
• Kristin Daniel

Friend

• Yogesh Goyal

Co-Mentee

• Maddie Wu
• Chien-Yu (Chihiro) Huang
• Hsiang Hong

Principal Investigator

• Ian Mellis

portals

• GTExPortal

portal

• GTExPortal

papers

• VYD2311 is a promising candidate for passive immunization against COVID-19 in immunocompromised individuals
• LP. 8.1-directed COVID-19 mRNA vaccines durably boost neutralizing antibodies and mitigate ancestral immune imprinting
• Variant-specific antibody correlates of protection against SARS-CoV-2 Omicron symptomatic and overall infections
• Antibody evasion and receptor binding of SARS-CoV-2 LP.8.1.1, NB.1.8.1, XFG, and related subvariants
• Optimizing a human monoclonal antibody for better neutralization of SARS-CoV-2
• Do Existing COVID-19 Vaccines Need to Be Updated in 2025?
• Antibody evasiveness of SARS-CoV-2 subvariants KP.3.1.1 and XEC
• KP.2-based monovalent mRNA vaccines robustly boost antibody responses to SARS-CoV-2
• Robust SARS-CoV-2-neutralizing antibodies sustained through 6 months post XBB.1.5 mRNA vaccine booster
• Recurrent SARS-CoV-2 spike mutations confer growth advantages to select JN.1 sublineages
• Prevalence of and gene regulatory constraints on transcriptional adaptation in single cells
• SARS-CoV-2 Omicron BA.2.87.1 Exhibits Higher Susceptibility to Serum Neutralization Than EG.5.1 and JN.1
• XBB.1.5 monovalent mRNA vaccine booster elicits robust neutralizing antibodies against XBB subvariants and JN.1
• Retrospective identification of intrinsic factors that mark pluripotency potential in rare somatic cells
• Evolving antibody evasion and receptor affinity of the Omicron BA.2.75 sublineage of SARS-CoV-2
• Diverse clonal fates emerge upon drug treatment of homogeneous cancer cells
• SARS-CoV-2 Neutralizing Antibodies After Bivalent vs. Monovalent Booster
• Cell type determination for cardiac differentiation occurs soon after seeding of human induced pluripotent stem cells
• Responsiveness to perturbations is a hallmark of transcription factors that maintain cell identity in vitro
• Association of Neighborhood-Level Factors and COVID-19 Infection Patterns in Philadelphia Using Spatial Regression
• Genetic screening for single-cell variability modulators driving therapy resistance
• Remodeling of the collagen matrix in aging skin promotes melanoma metastasis and affects immune cell motility
• Allele-specific RNA imaging shows that allelic imbalances can arise in tissues through transcriptional bursting
• ClampFISH detects individual nucleic acid molecules using click chemistry–based amplification
• Visualizing adenosine to inosine RNA editing in single mammalian cells
• An Alzheimer’s disease-derived biomarker signature identifies Parkinson’s disease patients with dementia
• Half dozen of one, six billion of the other: What can small- and large-scale molecular systems biology learn from one another?
• Conditionals by inversion provide a universal method for the generation of conditional alleles

paper

• VYD2311 is a promising candidate for passive immunization against COVID-19 in immunocompromised individuals
• LP. 8.1-directed COVID-19 mRNA vaccines durably boost neutralizing antibodies and mitigate ancestral immune imprinting
• Variant-specific antibody correlates of protection against SARS-CoV-2 Omicron symptomatic and overall infections
• Antibody evasion and receptor binding of SARS-CoV-2 LP.8.1.1, NB.1.8.1, XFG, and related subvariants
• Optimizing a human monoclonal antibody for better neutralization of SARS-CoV-2
• Do Existing COVID-19 Vaccines Need to Be Updated in 2025?
• Antibody evasiveness of SARS-CoV-2 subvariants KP.3.1.1 and XEC
• KP.2-based monovalent mRNA vaccines robustly boost antibody responses to SARS-CoV-2
• Robust SARS-CoV-2-neutralizing antibodies sustained through 6 months post XBB.1.5 mRNA vaccine booster
• Recurrent SARS-CoV-2 spike mutations confer growth advantages to select JN.1 sublineages
• Prevalence of and gene regulatory constraints on transcriptional adaptation in single cells
• SARS-CoV-2 Omicron BA.2.87.1 Exhibits Higher Susceptibility to Serum Neutralization Than EG.5.1 and JN.1
• XBB.1.5 monovalent mRNA vaccine booster elicits robust neutralizing antibodies against XBB subvariants and JN.1
• Retrospective identification of intrinsic factors that mark pluripotency potential in rare somatic cells
• Evolving antibody evasion and receptor affinity of the Omicron BA.2.75 sublineage of SARS-CoV-2
• Diverse clonal fates emerge upon drug treatment of homogeneous cancer cells
• SARS-CoV-2 Neutralizing Antibodies After Bivalent vs. Monovalent Booster
• Cell type determination for cardiac differentiation occurs soon after seeding of human induced pluripotent stem cells
• Responsiveness to perturbations is a hallmark of transcription factors that maintain cell identity in vitro
• Association of Neighborhood-Level Factors and COVID-19 Infection Patterns in Philadelphia Using Spatial Regression
• Genetic screening for single-cell variability modulators driving therapy resistance
• Remodeling of the collagen matrix in aging skin promotes melanoma metastasis and affects immune cell motility
• Allele-specific RNA imaging shows that allelic imbalances can arise in tissues through transcriptional bursting
• ClampFISH detects individual nucleic acid molecules using click chemistry–based amplification
• Visualizing adenosine to inosine RNA editing in single mammalian cells
• An Alzheimer’s disease-derived biomarker signature identifies Parkinson’s disease patients with dementia
• Half dozen of one, six billion of the other: What can small- and large-scale molecular systems biology learn from one another?
• Conditionals by inversion provide a universal method for the generation of conditional alleles

misc

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home

• The Mellis Lab

projects

• Cellular engineering and therapies
• Harnessing mechanisms of gene regulation
• Virus evolution and immune evasion
• Virus-neutralizing antibodies

project

• Cellular engineering and therapies
• Harnessing mechanisms of gene regulation
• Virus evolution and immune evasion
• Virus-neutralizing antibodies

events

• New K08 Funding
• Sofiia Shapovalova joins
• Kristin Daniel joins
• Mellis Lab Opens!

positions

• Postdoctoral Research Scientist

position

• Postdoctoral Research Scientist